Effects of Quaternary Ammonium Chitin Derivatives on Antibacterial Properties

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Effects of Quaternary Ammonium Chitin Derivatives on Antibacterial Properties

Mr. Tirut Morkaew: Master Degree Student, Major Applied Polymer Science and Textile Technology, Department of Materials Science, Faculty of Science, Chulalongkorn University. Onruthai Pinyakong: Assistant Professor Doctor, Deparment of Microbiology, Faculty of Science, Chulalongkorn University. Wanpen Tachaboonyakiat: Assistant Professor Doctor, Major Applied Polymer Science and Textile Technology, Department of Materials Science, Faculty of Science, Chulalongkorn University.

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Two quaternary ammonium chitins containing carboxymethyl trimethylammonium chloride (CTA) and 3-Carboxypropyl trimethylammonium chloride (CPA) were synthesized by coupling chitin with the quaternary ammoniums (CTA and CPA) using dicyclohexyl carbodiimide (DCC) as a coupling agent in dimethylacetamide/5%lithium chloride solution. FTIR spectroscopy analysis showed the forming of ester linkage from quaternary ammonium chitin derivatives. Antibacterial activity of the quaternary ammonium chitin derivatives were evaluated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by investigating the reduction percentage. All the quaternary ammonium chitin derivatives showed better antibacterial property than chitin. The derivatives were effective to E. coli than S. aureus and CTCPA could inhibit the growth of S. aureus better than CTCTA.

Keywords: Chitin, Quaternary Ammonium, Antibacteria, Esterificaton